I used the 241C for the added trans oil pan/driveshaft clearance. The 241C really needs a slip yoke eliminator (in my opinion). I used JB conversions on mine. I also used a $50 ebay clocking ring to clock it up. A passenger drop 241C isn't easy to find, but also not that difficult. The Dana 300 needs an adaptor to work with the GM trans.
There are different schools of thought on strength. The 300 has a cast iron case and is gear driven. The 241C has an aluminum case with planetary reduction/chain driven front. That said, both have successfully been used behind big power with big tires. The 241 has a slightly deeper low range. You can twin stick the 300 for independent FWD and RWD combinations, the 241 cannot.
All that said, I am happy with my 241 and would prefer it over the 300 just because of how much better it shifts.